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Farmacocinética, cuidado del paciente y bioética traslacional
Artículos JCR
Cristina Muñoz Contreras, Ignacio Segarra Taús, Francisco Javier López Román, Raul Nieto Galera, Begoña Cerdá Martínez Pujalte. 2022. Role of caregivers on medication adherence management in polymedicated patients with Alzheimer's disease or other types of dementia. Frontiers in Public Health. Volumen 10:987936.. Páginas 1 - 10.
Ignacio Macpherson Mayol, Maria Victoria Roque Sanchez, J C Martín, Ignacio Segarra Taús. 2022. Analysis in the ethical decision‐making of dental, nurse and physiotherapist students, through case‐based learning (CBL). European Journal of Dental Education. Volumen 26. Páginas 277 - 287.
Lydia de Salazar, Ignacio Segarra Taús, Francisco Javier López Román, Antonio Torregrosa Garcia, Silvia Pérez Piñero, Vicente Ávila Gandía. 2021. Increased Bioavailability of β-Alanine by a Novel Controlled-Release Powder Blend Compared to a Slow-Release Tablet. Pharmaceutics. Volumen 13. Páginas 1517 - 1517.
Ignacio Macpherson Mayol, Maria Victoria Roque Sanchez, Ignacio Segarra Taús. 2020. Moral dilemmas involving anthropological and ethical dimension in healthcare curriculum. Nursing ethics. Volumen 27. Páginas 1238 - 1249.
Ignacio Macpherson Mayol, Maria Victoria Roque Sanchez, Ignacio Segarra Taús. 2019. Ethical challenges of germline genetic enhancement. Frontiers In Genetics. Volumen 10. Páginas 1 - 12.
Ignacio Macpherson Mayol, Maria Victoria Roque Sanchez, Ignacio Segarra Taús. 2019. Moral enhancement, at the peak of pharmacology and at the limit of ethics. Bioethics. Volumen 33. Páginas 992 - 1001.
I. Macpherson, Ignacio Segarra Taús. 2017. Commentary: Grand challenge: ELSI in a changing global environment. Front. Genet.. Volumen 8. Páginas 1 - 2.
C. C. Chew, S. Ng, Y. L.. Chee, T. W. Koo, M. H. Liew, E. L. Chee, P. Modamio, C. Fernandez, E. L. Mariño, Ignacio Segarra Taús. 2017. Diclofenac sex-divergent drug-drug interaction with sunitinib: pharmacokinetics and tissue distribution in male and female mice. Invest. New Drugs. Volumen 35(4). Páginas 399 - 411.
Ignacio Segarra Taús, Pilar Modamio, Cecilia Fernandez, Eduardo Mariño. 2017. Sex-Divergent Clinical Outcomes and Precision Medicine: An Important New Role for Institutional Review Boards and Research Ethics Committees. Front. Pharmacol.. Volumen 8. Páginas 1 - 10.
M. H. Liew, S. Ng, C. C. Chew, T. W. Koo, Y. L.. Chee, E. L. Chee, P. Modamio, C. Fernandez, E. L. Mariño, Ignacio Segarra Taús. 2017. Sunitinib-Paracetamol Sex-Divergent Pharmacokinetics and Tissue Distribution Drug-Drug Interaction in Mice. Invest. New Drugs. Volumen 35(2). Páginas 145 - 157.
Ignacio Segarra Taús, P. Modamio, C. Fernandez, E. L. Mariño. 2016. Sunitinib Possible Sex-Divergent Therapeutic Outcomes. Clin Drug Investig. Volumen 36(10). Páginas 791 - 799.
S. Y. Tan, M. M. Wong, A. L. Tiew, Y. W. Choo, S. H. Lim, I. H. Ooi, P. Modamio, C. Fernandez, E. L. Mariño, Ignacio Segarra Taús. 2016. Sunitinib DDI with paracetamol, diclofenac, mefenamic acid and ibuprofen shows sex-divergent effects on the tissue uptake and distribution pattern of sunitinib in mice.. Cancer Chemother Pharmacol. Volumen 78(4). Páginas 709 - 718.
Ignacio Macpherson Mayol, Maria Victoria Roque Sanchez, F Legget, Fernando Fuertes, Ignacio Segarra Taús. 2016. A systematic review of the relationship factor between women and health professionals within the multivariant analysis of maternal satisfaction. Midwifery. Volumen 41. Páginas 68 - 78.
Evelyn Chee, Adeline Lim, Pilar Modamio, Cecilia Fernandez Lastra, Ignacio Segarra Taús. 2016. Sunitinib tissue distribution changes after coadministration with ketoconazole in Mice. Eur J Drug Metab Pharmacokinet. Volumen 41(3). Páginas 309 - 319.
Christine Lau, Sook Tyng Chang, Manimega Selvaratanam, Hui Wen Khoo, Adeline Lim, Pilar Modamio, Eudardo Mariño, Ignacio Segarra Taús. 2015. Sunitinib-Ibuprofen drug interaction affects the pharmacokinetics and tissue distribution of sunitinib to brain, liver and kidney in male and female mice differently. Fundam Clin Pharmacol. Volumen 29(4). Páginas 404 - 416.
Ana Faura, Pilar Modamio, Domingo Blanco, Ignacio Segarra Taús, Cecilia Fernandez Lastra, Elisensa Izquierdo, Tomas Casasin, Eduardo Luis Mariño. 2015. Is the pharmacokinetics of bupivacaine equivalent after lumbar epidural administration through a needle or a catheter in male and female adults?. Biomed & Pharmacother. Volumen 70. Páginas 119 - 122.
O. Montejo, P. Modamio, C. Fernandez Lastra, Ignacio Segarra Taús, N. Mestorino, E. L. Mariño Hernández. 2015. Twenty-Week Solid-State Stability Study of Combined Doxycycline, Trimethoprim and Sulfamethoxypyridazine Formulations after Extemporaneous Preparation for Veterinary Use. Pak Vet J. Volumen 35(1). Páginas 111 - 113.
Ignacio Segarra Taús, Manuel Gómez. 2014. A Learning Activity to Introduce Undergraduate Students to Bioethics in Human Clinical Research: A Case Study. J Empir Res Hum Res Ethics. Volumen 6(5). Páginas 56 - 63.
J R Tan, S Chakravarthi, J P Judson, N Haleagrahara, Ignacio Segarra Taús. 2013. Potential protective effect of sunitinib after administration of diclofenac: biochemical and histopathological drug-drug interaction assessment in a mouse model.. Naunyn Schmiedebergs Arch Pharmacol. Volumen 386. Páginas 619 - 633.
w: K. Chew, Ignacio Segarra Taús, S. Ambu, J. W. Mak. 2012. Significant reduction of brain cysts caused by Toxoplasma gondii after treatment with spiramycin coadministered with metronidazole in a mouse model of chronic toxoplasmosis. Antimicrob Agents Chemother. Volumen 56. Páginas 1762 - 1768.
W. K. Chew, M. J. Wah, S. Ambu, Ignacio Segarra Taús. 2012. Toxoplasma gondii: Determination of the onset of chronic infection in mice and the in vitro reactivation of brain cysts. Exp Parasitol. Volumen 130. Páginas 22 - 25.
S. Y. Tan, K. Kan, W. Y. Lim, G. Chay, J. H. K. Law, G. W. Soo, N. I. Bukhari, Ignacio Segarra Taús. 2011. Metronidazole leads to enhaced uptake of imatinib in brain, liver and kidney without affecting its plasma pharmacokinetics in mice.. J Pharm Pharmacol. Volumen 63. Páginas 918 - 925.
W. K. Chew, Ignacio Segarra Taús. 2011. Simultaneous HPLC determination of metronidazole and spiramycin in plasma and brain of mouse. Curr Pharm Anal. Volumen 7(4). Páginas 213 - 227.
G. W. Soo, J. H. K. Law, E. Kan, S. Y. Tan, W. Y. Lim, G. Chay, N. I. Bukhari, Ignacio Segarra Taús. 2010. Differential effects of ketoconazole and primaquine on the pharmacokinetics and tissues distribution of imatinib in mice. Anticancer drugs. Volumen 21. Páginas 695 - 703.
M. Teoh, S. Radhakrisman, K. S. Moo, P. Narayanan, P. Ramkuman, N. I. Bukhari, Ignacio Segarra Taús. 2010. Pharmacokinetics, Tissue Distribution and Bioavailability of Imatinib in Mice after Administration of a Single Oral and an Intravenous Bolus Dose. Lat Am J Pharm. Volumen 29(3). Páginas 428 - 435.
M. Teoh, P. Narayanan, K. S. Moo, S. Radhakrisman, R. Pillappan, N. I. Bukhari, Ignacio Segarra Taús. 2010. HPLC determination of imatinib in plasma and tissues after multiple oral dose administration to mice. Pak J Pharm Sci. Volumen 23(1). Páginas 35 - 41.
I. Nassar, T. Pasupati, J. P. Judson, Ignacio Segarra Taús. 2009. Reduced Exposure of Imatinib after Coadministration with Acetaminophen to Mice. Indian J Pharmacol. Volumen 41(4). Páginas 167 - 172.
Ignacio Segarra Taús, D. A. Movshin, L. Zarif. 2002. Pharmacokinetics and tissue distribution after intravenous administration of single dose of amphotericin B cochleates, a new lipid-based delivery system. J Pharm Sci. Volumen 91(8). Páginas 1827 - 1837.
B. Hausen, K. Boeke, G. J. Berry, Ignacio Segarra Taús, L. Z. Benet, U. Christians, R. E. Morris. 1999. Coadministrations of Neoral and the novel rapamycin analog, SDZ RAD, to rat lung allograft recipients: potentiation of immunosupressive efficacy and improvement of tolerability by staggered versus simultaneous treatment. Transplantation. Volumen 67. Páginas 956 - 962.
B. Hausen, K. Boeke, G. J. Berry, Ignacio Segarra Taús, U. Christians, R. E. Morris. 1999. Supression of acute rejection in allogeneic rat lung transplantion: A study of the efficacy and pharmacokinetics of rapamycin derivative (SDZ RAD) used alone and in combination with a microemulsion formulation of cycloporine. J Heart Lung Transplant. Volumen 18. Páginas 150 - 159.
Ignacio Segarra Taús, Timothy Brazelton, N. Guterman, B. Hausen, W. Jacobsen, R. E. Morris, L. Z. Benet, U. Christians. 1998. Development of a high-performance liquid chromatographic-electroscopray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-o- (2-hydroxyethyl) rapamycin. J Chromatogr B Biomed Sci Appl. Volumen 720. Páginas 179 - 187.
Capítulos de libro
María Victoria Bernardo Pisa. 2018. Separación de sustancias. Aran. Páginas 146 - 196.
Otros Artículos
Kian Kuang Tan, Yew-Beng Kang, Ignacio Segarra Taús, Ummarah Kanwal, Muhammad Ahsan, Nadeem Bukhari. 2021. Microwave-Assisted Preparation of Cross-Linked Gelatin-Paracetamol Matrices: Optimization using D-Optimal design. Turkish Journal of Pharmaceutical Sciences. Volumen 18. Páginas 167 - 175.
D. Ezpeleta, Ignacio Segarra Taús. 2017. Transhumanism on artificial intelligence portrayed in selected science fiction movies and TV series. MEDIC. Volumen 25(1). Páginas 64 - 68.
N. Mestorino, M. L. Marchetti, M. F. Lucas, P. Lucas, P. Zeinsteger, C. Fernandez Lastra, Ignacio Segarra Taús, E. L. Mariño. 2016. Bioequivalence study of two long-acting formulations of oxytetracycline following intramuscular administration in bovines. Front. Vet. Sci.. Volumen 3(50). Páginas 1 - 8.
A. Y. L. Lim, Ignacio Segarra Taús, S. Chakravarthi, S. Akram, J. P. Judson. 2010. Histopathology and biochemistry analysis of the interaction between sunitinib and paracetamol in mice. BMC Pharmacol. Volumen 10(14). Páginas 1 - 17.
K. S. Moo, M. Teoh, S. Radhakrisman, P. Narayanan, N. I. Bukhari, Ignacio Segarra Taús. 2010. Disposition and tissue distribution of imatinib after intravenous bolus dose to mice in a liposome formulation. Acta Pharmaceutica Sinica. Volumen 45(7). Páginas 901 - 908.
I. Nassar, T. Pasupati, J. P. Judson, Ignacio Segarra Taús. 2010. Histopathological Study of the Hepatic and Renal Toxicity Associated to the Coadministration of Imatinib and Acetaminophen in a Preclinical Mouse Model. Mal J Path. Volumen 32(1). Páginas 1 - 11.
Ignacio Segarra Taús, Virginia Merino, Santiago Fabra, Teresa María Garrigues, Adela Martin Villodre. 1995. Alternative chromatographic parameters: their utility as lipophilicity indexes. Ciencia Pharm. Volumen 5. Páginas 19 - 26.
Proyectos no competitivos
Diseño de un producto en formato gel con propiedades antioxidantes y antiinflamatorias.. OLEA INVESTIGACIONES, AIE (V72997612). (2024-2025)
Estudio de la eficacia de un suplemento basado en caqui en personas con sobrepeso y obesidad. DUCULA INVESTIGACIONES, AIE (V72997968). (2023-2023)
Regenerative Implantology. MIS International. (2012-2015)
Antiviral efficacy of Luminide technology in a murine infected model. Luminide Pharmaceuticals Corp.. (2001-2002)
Application of cochleate technology for drug delivery in IVAP-intestinal and vascular access port- dog model. BioDelivery Sciences International, Inc. (2001-2002)
Mode of action study. Elan Corporation. (2001-2002)
A single-dose pharmacology/ pharmacokinetic study of novel hexyl insulin derivative formulations administered orally to dogs. Nobex Corporation Inc. (2000-2002)
Bioavailability and pharmacokinetics of decitabine in IVAP rabbits. SuperGen Inc. (2000-2003)
Bioavailability and pharmacokinetics of pentostatin (Nipent®) in a multi-ported dog model (IVAP. SuperGen Inc. (2000-2002)
Biopharmaceutical study and bioavailability of 9-Amino-Camptothecin in multi-ported beagle dogs. SuperGen Inc. (2000-2002)
Oral delivery of low molecular weight heparin in dogs. Elan Corporation. (2000-2002)
Oral delivery of oligonucleotides. Intestinal motility study. ISIS Pharmaceuticals Inc.. (2000-2001)
Proyectos competitivos
Drug-Drug Interaction Study of Sunitinib (Sutent®) and diclofenac in a Mouse Model: Biochemical and Histopathological Assessment. International Medical University. (2010-2010)
Pharmacokinetic drug-drug interactions of sunitinib (Sutent®) after multiple dose administration in a mouse model. International Medical University. (2010-2011)
Drug-Drug Interaction Study of Sunitinib (Sutent®) in a Mouse Model: Biochemical and Histopathological Assessment. International Medical University. (2009-2009)
Pharmacokinetic drug-drug interactions of sunitinib (Sutent®): effects on the plasma, tissue disposition profiles and biomarkers in a mouse model. International Medical University. (2009-2009)
Analysis of the effect of BLOQ data treatment on the pharmacokinetic parameters outcome. International Medical University. (2008-2010)
Development of therapeutic model of toxoplasmosis in mice. International Medical University. (2008-2011)
Drug-drug interaction between imatinib and acetaminophen – Pharmacokinetics and histopathological studies in mice. International Medical University. (2008-2008)
Effect of drug-drug interactions on the pharmacokinetics and tissue distribution of Imatinib in mice. International Medical University. (2008-2009)
Effect of surfactant on the lipophilicity parameters of selected model drugs. International Medical University. (2008-2009)
Effect of surfactants on the pharmacokinetics and efficacy of anti-fungal agents. International Medical University. (2008-2010)
Enhancement of tissue distribution of griseofulvin by a unique combination of drug with CTAB and inhibitor of first pass metabolism. International Medical University. (2008-2009)
Study of fitting factors (weighting factor) as a computational variable for drug pharmacokinetics assuming different compartment models. International Medical University. (2008-2009)
Study on the combined effect of microwave and cross-linking on the release of paracetamol, a water-soluble model drug from gelatin using optimization algorithms. International Medical University. (2008-2009)
Improving water solubility of drugs by using simple approach of employing surfactants. International Medical University. (2007-2008)
Study of imatinib pharmacokinetics and tissue distribution after administration in a liposome based formulation. International Medical University. (2007-2008)