%20--%3e%3csvg%20version='1.1'%20id='Capa_1'%20xmlns='http://www.w3.org/2000/svg'%20xmlns:xlink='http://www.w3.org/1999/xlink'%20x='0px'%20y='0px'%20viewBox='0%200%20114.1%2024.9'%20style='enable-background:new%200%200%20114.1%2024.9;'%20xml:space='preserve'%3e%3cstyle%20type='text/css'%3e%20.st0{fill:%23FFFFFF;}%20%3c/style%3e%3cg%3e%3cg%3e%3cg%3e%3cpath%20class='st0'%20d='M0.6,0.1c1.8,0,3.6,0.1,4.6,0.1c0.8,0,2.8-0.1,4-0.1c0.5,0,0.8,0.1,0.8,0.3S9.8,0.7,9.4,0.7%20c-0.4,0-0.3,0-0.7,0.1C7.9,0.9,7.6,1.4,7.5,2.5c-0.1,1-0.1,1.9-0.1,6.8v4.5c0,4.6,0.9,6.6,2.5,7.9c1.5,1.2,2.7,1.3,3.8,1.3%20c1.4,0,3-0.5,4.3-1.7c1.8-1.8,1.9-4.6,1.9-7.9V9.5c0-4.9,0-5.7-0.1-6.8c-0.1-1.1-0.3-1.6-1.4-1.8c-0.3-0.1-0.7-0.1-0.9-0.1%20c-0.4,0-0.6-0.1-0.6-0.3s0.2-0.3,0.7-0.3c1.7,0,3.8,0.1,3.8,0.1c0.4,0,2.4-0.1,3.8-0.1c0.5,0,0.7,0.1,0.7,0.3s-0.2,0.3-0.6,0.3%20s-0.4,0-0.8,0.1c-0.8,0.2-1.1,0.7-1.2,1.8c-0.1,1-0.1,1.9-0.1,6.8v3.4c0,3.6-0.4,7.3-3.1,9.6c-2.3,2-4.9,2.3-7,2.3%20c-1.8,0-6,0-8.4-2.2c-1.7-1.5-2.9-3.8-2.9-8.4V9.5c0-4.9,0-5.7,0-6.8c0-0.9,0.1-1.4-0.3-1.8C1.3,0.8,1.2,0.8,0.9,0.8S0,0.7,0,0.5%20C0.1,0.2,0.2,0.1,0.6,0.1'/%3e%3cpath%20class='st0'%20d='M31.3,21.2c-3.2-2.7-4-6.2-4-9.2c0-2.2,0.7-5.8,3.8-8.5c2.3-2.1,5.3-3.3,10.2-3.3c2,0,3.2,0.1,4.7,0.3%20c1.2,0.2,2.3,0.5,3.2,0.6c0.4,0,0.5,0.2,0.5,0.4c0,0.3-0.1,0.7-0.2,1.7c-0.1,1,0,2.7-0.1,3.4c0,0.5-0.1,0.8-0.4,0.8%20c-0.3,0-0.3-0.3-0.3-0.7c0-0.9-0.5-2.1-1.2-2.9c-1-1.1-2.7-1.8-5.6-1.8c-2.8,0-3.9,0.7-5.3,2c-2.3,2.1-3,5.1-3,8.1%20c0,7.4,5.8,11.2,10.1,11.2c2.9,0,3.1-0.1,4.4-1.5c0.6-0.6,0.9-1.9,1-2.4c0.1-0.5,0.2-0.7,0.5-0.7c0.2,0,0.3,0.2,0.3,0.5%20c0,0.4-0.4,3.1-0.8,4.1c-0.2,0.6-0.3,0.7-0.8,0.9c-1.3,0.5-3.8,0.8-5.8,0.8C37.9,24.6,34.2,23.6,31.3,21.2'/%3e%3cpath%20class='st0'%20d='M86,0.8c0.3-0.6,0.8-0.7,0.8-0.7c0.3,0,0.6,0.1,0.9,0.6l8.8,17.7l8.6-17.4c0.3-0.5,0.7-0.8,0.9-0.8%20c0.4,0,0.8,0.4,0.8,0.9l2.9,19.4c0.3,2,0.7,2.9,1.6,3.2c0.9,0.3,1.1,0.4,1.5,0.4c0.3,0,0.5,0,0.5,0.2c0,0.3-0.4,0.4-0.8,0.4%20c-0.8,0-5.3-0.1-6.6-0.2c-0.8-0.1-0.9-0.2-0.9-0.4s0.1-0.3,0.4-0.4c0.2-0.1,0.3-0.5,0.2-1.3l-2-13.8h0.1l-7,14.3%20c-0.8,1.5-1,1.7-1.5,1.7S94.4,24,94,23.1c-0.8-1.4-3.4-6.3-3.8-7.1c-0.3-0.7-2.3-4.6-3.4-6.9h0.4l-1.7,12.5%20c-0.1,0.6-0.1,0.9-0.1,1.5c0,0.6,0.5,0.8,0.9,1c0.6,0.1,1,0.2,1.3,0.2c0.3,0,0.5,0.1,0.5,0.2c0,0.3-0.3,0.4-0.8,0.4%20c-1.4,0-2.8-0.1-3.4-0.1c-0.7,0-2.2,0.1-3.2,0.1c-0.3,0-0.6-0.1-0.6-0.4c0-0.2,0.2-0.2,0.5-0.2s0.5,0,0.9-0.1%20c0.9-0.2,1-1.7,1.2-2.7L86,0.8z'/%3e%3cpath%20class='st0'%20d='M61.1,17.4c-0.3,0.1-0.9,0.3-1.3,0.9l-1.2,2.7C58.2,21.9,58,22.6,58,23c0,0.6,0.3,0.9,1.3,0.9h0.5%20c0.4,0,0.5,0.1,0.5,0.3c0,0.3-0.2,0.3-0.6,0.3c-1,0-2.4-0.1-3.5-0.1c-0.4,0-2.2,0.1-3.8,0.1c-0.5,0-0.7-0.1-0.7-0.3%20s0.1-0.3,0.4-0.3c0.3,0,0.8,0,1-0.1c1.5-0.2,2-1.6,2.6-3.2l8.2-19.7C64.2,0,65,0,65.1,0c0.3,0,0.6,0.2,1,1%20C67,2.7,72,15.6,74.2,20.4c1.2,2.8,2.2,3.3,2.8,3.4c0.5,0.1,0.6,0.1,0.9,0.1c0.3,0,0.5,0,0.5,0.3s-0.3,0.3-1.5,0.3%20c-1.1,0-3.6,0-6.1-0.1c-0.6,0-0.9,0-0.9-0.3c0-0.2,0.1-0.3,0.5-0.3c0.2-0.1,0.5-0.4,0.3-0.8l-2.2-4.8c-0.1-0.2-0.8-0.8-1.3-0.9%20C67.1,17.4,61.2,17.4,61.1,17.4%20M61.1,15.4c1.1,0.1,4.2,0.1,5.7,0c0.3,0,0.5-0.4,0.4-0.7l-2.7-7.8c-0.1-0.1-0.1-0.3-0.2-0.3%20c-0.1,0-0.2,0.2-0.2,0.3l-3.2,7.8C60.7,15,60.7,15.3,61.1,15.4'/%3e%3c/g%3e%3c/g%3e%3c/g%3e%3c/svg%3e){kind=small}
Metabolismo y Regulación Génica de Enfermedades
Artículos JCR
Tomoaki Hishida, Mako Yamamoto, Yuriko Hishida-Nozaki, Changwei Shao, Ling Huang, Chao Wang, Kensaku Shojima, Yuan Xue, Yuqing Hang, Maxim Shokhirev, Sebastian Memczak, Sanjeeb Kumar Sahu, Fumiyuki Hatanaka, Rubén Rabadán Ros, Matthew B Maxwell, Jasmine Chavez, Yanjiao Shao, Hsin-Kai Liao, Paloma Martinez-Redondo, Isabel Guillen-Guillen, Reyna Hernandez-Benitez, Concepcion Rodriguez Esteban, Jing Qu, Michael C Holmes, Fei Yi, Raymond D Hickey, Pedro Guillén García, Maria Estrella Nuñez Delicado, Antoni Castells, Josep M Campistol, Diana C Hargreaves, Yang Yu, Akihiro Asai, Pradeep Reddy, Guang-Hui Liu, Juan Carlos Izpisua Belmonte. 2022. In vivo partial cellular reprogramming enhances liver plasticity and regeneration. Cell reports. Volumen 38. Páginas 110730 - 110730.
Jose Tomás Cánovas Márquez, Sebastian Falk, Rubén Zapata Pérez, Francisco E. Nicolás, S. Padmanabhan, Álvaro Sánchez Ferrer, Eusebio Navarro, Victoriano Garre, 2021. A ribonuclease III involved in virulence of Mucorales fungi has evolved to cut single-stranded RNA PMID: 33877360. Nucleic Acids Research. Volumen 49. Páginas 5294 - 5307.
N.J. Connell, L. Grevendonk, C. Fealy, E. Kornips Moonen, Y. Bruls, V. Schrauwen Hinderling, J. de Vogel, R. Hageman, J. Geurts, R. Zapata Pérez, R.H. Houtkooper, B. Havekes, J. Hoeks, P. Schrauwen. 2021. NAD+-precursor supplementation with L-tryptophan, nicotinic acid, and nicotinamide does not improve mitochondrial function and skeletal muscle function in physically compromised older adults PMID: 34191033. Journal of Nutrition. Volumen 151. Páginas 2917 - 2931.
Rubén Zapata Pérez, Riekelt H. Houtkooper, 2020. Enzyme engineering to fight mitochondrial diseases PMID: 32694771. Nature Metabolism. Volumen 2. Páginas 215 - 216.
C.M.E Remie, K.H.M Roumans, M.P.B Moonen, N.J. Connell, B. Havekes, J. Mevenkamp, L. Lindeboom, V.H.W. de Wit, T. van de Weijer, S.A.B.M. Aarts, E. Lutgens, B.V. Schomakers, H.L. Elfrink, R. Zapata Pérez, R.H. Houtkooper, J. Hoeks, V.B. Schrauwen Hinderling, E. Phielix, P. Schrauwen. 2020. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine levels in humans PMID: 32320006. American Journal of Clinical Nutrition. Volumen 112. Páginas 413 - 426.
Rubén Rabadán Ros, Beatriz Revilla Nuin, Patricia Mazón, Salvador David Aznar Cervantes, Patricia Ros Tárraga, Piedad N. de Aza Moya, Luis R. Meseguer Olmo. 2018. Impact of a porous Si-Ca-P monophasic ceramic on variation of osteogenesis-related gene expression of adult human mesenchymal stem cells.. Applied Sciences,. Volumen 8. Páginas 46 - 58.
Rubén Rabadán Ros. 2017. In vitro behaviour of Nurse's A ss-phase: A new calcium silicophosphate ceramic.. Journal of the European Ceramic Society. Volumen 37. Páginas 2943 - 2952.
Iliana Chatzispyrou, Marielle Alders, Rubén Zapata Pérez, Sergio Guerrero Castillo, Martin Haagmans, Laurent Mouchiroud, Janet Koster, Rob Ofman, Frank Baas, Hans Waterham, Johannes Spelbrink, Johan Auwerx, Marcel Mannens, Riekelt Houtkooper, Astrid Plomp. 2017. A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault Syndrome PMID: 28449065. Human Molecular Genetics. Volumen 13. Páginas 2541 - 2550.
Ana Belén Martínez Moñino, Rubén Zapata Pérez, Antonio Ginés García Saura, Juana Cabanes, Álvaro Sánchez Ferrer. 2017. A new cross-linked enzyme aggregate biocatalyst for a NAD+-booster production DOI: doi.org/10.1039/C7RA00505A. RSC Advances. Volumen 7. Páginas 14272 - 14278.
Rubén Zapata Pérez, Fernando Gil Ortiz, Ana Belén Martínez Moñino, Antonio Ginés García Saura, Jordi Juanhuix, Álvaro Sánchez Ferrer. 2017. Structural and functional analysis of Oceanobacillus iheyensis macrodomain reveals a network of waters involved in substrate binding and catalysis PMID: 28446708. Open Biology. Volumen 4. Páginas 160327 - 160327.
Rubén Rabadán Ros. 2016. Assessment of Effects of Si-Ca-P Biphasic Ceramic on the Osteogenic Differentiation of a Population of Multipotent Adult Human Stem Cells.. Materials (Basel, Switzerland). Volumen 9. Páginas 969 - 969.
Rubén Zapata Pérez, Antonio Ginés García Saura, Mohamed Jebbar, Peter Golyshin, Álvaro Sánchez Ferrer. 2016. Combined Whole-Cell High-Throughput Functional Screening for Identification of New Nicotinamidases/Pyrazinamidases in Metagenomic/Polygenomic Libraries PMID: 28018295. Frontiers In Microbiology. Volumen 7. Páginas 1915 - 1915.
Sylwia Tyrkalska, Rubén Zapata Pérez, Sergio Candel, Diego Angosto, Victoria Gómez Avellán, Fátima Martín Sánchez, Diana García Moreno, Álvaro Sánchez Ferrer, María Sepulcre, Pablo Pelegrín, Victoriano Mulero. 2016. Neutrophils mediate Salmonella typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins PMID: 27363812. Nature Communications. Volumen 7. Páginas 12077 - 12077.
Otros Artículos
Chao Wang, Rabadán Ros, Izpisua Belmonte. 2021. In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche. Nature Communications. Volumen 12. Páginas 1 - 15.
Patricia Ros Tárraga, Rubén Rabadán Ros, Patricia Mazón, Beatriz Revilla Nuin, Piedad N de Aza Moya, Luis Meseguer Olmo. 2020. High temperature CaSiO3–Ca3 (PO4) 2 ceramic promotes osteogenic differentiation in adult human mesenchymal stem cells. Materials Science and Engineering: C. Volumen 107. Páginas 110355 - 110355.
Proyectos competitivos
Alimentos funcionales antienvejecimiento con potenciadores de NAD+ mejorados con sustancias naturales bioactivas. Ministerio de Ciencia, Innovación y Universidades (MICINN). (2024-2027)
Improving physical performance and cardiac function of Tafazzin deficient mice with nicotinamide riboside. Barth Syndrome Foundation (BSF). (2023-2024)
POTENCIADORES DE NAD+ Y MODULADORES REDOX COMO NUEVAS TERAPIAS FRENTE A ENFERMEDADES MITOCONDRIALES. Fundación Séneca - Agencia de Ciencia y Tecnología de la Región de Murcia (SÉNECA). (2023-2025)
Enhancing brown adipose tissue metablism through supplementation with novel NAD precursors. Amsterdam Gastroenterology, Endocrinology and Metabolism Research Institute. (2020-2021)
MAT2016-75544-C2-1-R "Producción y evaluación de la respuesta biológica de fibras de seda de altas prestaciones para aplicaciones en terapias de tendones y ligamentos". Ministerio de Economía, Industria y Competitividad (MINECO). (2016-2019)
Biotechnological design of novel health-promoting compounds: enzymatic production, molecular stabilization and testing. Fundación Séneca. (2016-2017)
Deciphering the structural and functional basis of novel NAD+-utilizing enzymes with biomedical relevance. CELLS-ALBA Synchrotron. (2016-2016)
Structural evaluation of new NAD+-related and NAD+-modifying enzymes with interest in biomedical research. CELLS-ALBA Synchrotron. (2015-2015)
Structural analysis of new NAD+-related enzymes with biomedical relevance. CELLS-ALBA Synchrotron. (2014-2014)
Structure determination of new NAD+-consuming enzymes with potential pharmaceutical interest. CELLS-ALBA Synchrotron. (2013-2013)
Crystallization of sirtuin and sirtuin-related enzymes from extremophile microorganisms. CELLS-ALBA Synchrotron. (2012-2012)
Proyectos no competitivos
Metaverso: Transformando la Docencia Molecular y Celular. Universidad Católica de Murcia (G30626303). (2023-2024)
Desarrollo de nuevas terapias para la mejora de la trasplantabilidad del riñón donante. Inventium. (2023)
Development of ex vivo and in vivo organ rejuvenation strategies. Altos Labs (3303547227). (2022-2024)
Análisis metabolómico de muestras de distinto origen. Biowair Total Systems S.L. (B33998980). (2022-2023)
Mejora de la regeneración y las marcas de envejecimiento mediante la exposición a BioW. Biowair Total Systems S.L. (B33998980). (2022-2023)
sNADp (Synthesizing NAD+ precursors). Universidad Católica de Murcia (G30626303). (2021-2023)
MEJORA DE ENFERMEDADES RENALES MEDIANTE REPROGRAMACIÓN PARCIAL. Universidad Católica de Murcia (G30626303). (2021-2023)
Proyecto REVCKD2021: Regeneración y reversión del fenotipo de enfermedad renal mediante reprogramación celular parcial. Fundacio Clinic per a la Recerca Biomedica (G59319681). (2021-2023)
“GENERATION OF FUNCTIONAL AND CLINICAL RELEVANT ORGANS FROM HUMAN IPSCS USING INTERSPECIFIC BLASTOCYST COMPLEMENTATION”. Universidad Católica de Murcia (G30626303). (2021-2023)
"A Human IPS Cell-Based Model to Study Multiple Sclerosis Disease Onset and Progression".. Salk Institute for Biological Laboratories (G2928386). (2020-2023)
"Novel Therapeutics for the Treatment of rare Diseases and Use of Specific Metabolites for Cell Reprograming". Universidad Católica de Murcia (G30626303). (2019-2022)
Donación al proyecto "Epigenetic approaches to understand and treat aging". FUNDACIÓN PRIMAFRIO (G73996894). (2019-2020)
Fighting Human Diseases with New Genetic and Epigenetic Editing Technologies. Moxie Foundation. (2019-2021)
New genetic and epigenetic editing technologies for treating disease. H&H Evergreen Foundation. (2019-2021)
Donación al proyecto "Genetic strategies towards understanding and treating mitochondrial diseases". Fundación MENCÍA SOLER LAVÍN (G-66626359). (2018-2020)