Active Biopeptides from Spanish dry-cured ham: From in vivo to in vitro
Cardiovascular Disease (CVD) has traditionally been related to risk factors. However, a significant body of scientific data has revealed another layer of complexity, pointing to the need for a healthier diet and regular exercise in order to increase protection. Therefore, there is a clear need and a substantial market opportunity for developing new foods and beverages with proven benefits for cardiovascular health. Bioactive peptides display distinct bioactivities in vitro: ACE inhibition, DPPIV, antioxidant, antimicrobial etc. In this line, there are numerous reports of clinically significant effects of consuming bioactive peptides on blood pressure in humans which are also supported by reports in animal models of hypertension. This effect is the result of a flexible molecular behavior which allow them to easily interact with very distinct proteins/receptors in vitro and over the human body. However, few data can provide information on their specific molecular mechanism(s) and targets. And there is a great interest in decrypting molecular mechanisms of action of bioactive peptides in order to support cardiovascular-related health claims. Indeed, biological activity assessments have been almost exclusively limited to assays to detect antihypertensive, antioxidant and antiinflammatory effects of these bioactive peptides. The current seminary summarizes a whole research project were the biological activities of bioactive peptides from dry-cured pork ham have been tested in vivo and in vitro.